Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons
نویسندگان
چکیده
منابع مشابه
Differential modulation of I(h) by 5-HT receptors in mouse CA1 hippocampal neurons.
CA1 pyramidal neurons of the hippocampus express various types of serotonin (5-HT) receptors, such as 5-HT(1A), 5-HT(4) and 5-HT(7) receptors, which couple to Galpha(i) or Galpha(s) proteins and operate on different intracellular signalling pathways. In the present paper we verify such differential serotonergic modulation for the hyperpolarization-activated current I(h). Activation of 5-HT(1A) ...
متن کاملModulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes.
The subthalamic nucleus (STN) is considered to be one of the driving forces in the basal ganglia circuit. The STN is innervated by serotonergic afferents from the raphe nucleus and expresses a variety of 5-HT receptor subtypes. We investigated the effects of 5-HT and 5-HT receptor subtype agonists and antagonists on the firing properties of STN neurons in rat brain slices. We used cell-attached...
متن کاملVoltage-dependent calcium currents in trigeminal motoneurons of early postnatal rats: modulation by 5-HT receptors.
Trigeminal motoneurons relay the final output signals generated within the oral-motor pattern generating circuit(s) to muscles for execution of various motor patterns. In recent years, these motoneurons were shown to possess voltage dependent nonlinear membrane properties that allow them to actively participate in sculpting their final output. A complete understanding of the factors controlling...
متن کاملEffects of creatine monohydrate supplementation and exercise on depression-like behaviors and raphe 5-HT neurons in mice
PURPOSE The effects of creatine and exercise on chronic stress-induced depression are unclear. In the present study, we identified the effects of 4-week supplementation of creatine monohydrate and/or exercise on antidepressant behavior and raphe 5-HT expression in a chronic mild stress-induced depressed mouse model. METHODS Seven-week-old male C57BL/6 mice (n=48) were divided randomly into 5 ...
متن کاملElectroacupuncture restores hippocampal synaptic plasticity via modulation of 5-HT receptors in a rat model of depression
OBJECTIVE The study aimed to determine the effect of electroacupuncture (EA) on Wistar Kyoto (WKY) depressive model rats and explore the possible mechanism of EA on hippocampal CA1 region neuronal synaptic plasticity. METHODS The male WKY rats were randomized to three experimental groups (EA, Sham EA, and Model group, n = 8/group), and Wistar rats as the normal control group (n = 8). EA treat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2020
ISSN: 1359-4184,1476-5578
DOI: 10.1038/s41380-020-0649-0